Corresponding Author: Gerald C. Hsu, eclaireMD Foundation, USA.
This paper describes one of the author’s hypothetical theories on the relationship between life longevity and overall metabolism, the macro-system view, specifically the stress and daily life routine regularity, two micro-categories.
The author has spent ~25,000 hours over the past 8.5 years (2010-2019) to conduct his research on metabolism, endocrinology, and chronic diseases, especially diabetes.
He spent the entire year 2014 to establish a mathematical model of metabolism which includes 4 output categories (weight, glucose, blood pressure, and lipids) and 6 input categories (food, water, exercise, sleep, stress, and life routine regularity). There are approximately 500 detailed elements included in these 10 categories. The “theoretical development” and a complete set of their interactive relationships would be an immense task, which includes calculations of 500 ! – this step is a massive undertaking without any significant benefit. Therefore, the author assigned various weighting factors to these elements and to seek important but partial interactions to investigate. By utilizing concepts and methods of topology, nonlinear algebra from mathematics, and finite element method from structural and mechanical engineering, he was able to define an approximated metabolism mathematical model with two newly defined variables, metabolism index (MI) and general health status unit (GHSU), where the GHSU is the 90-days moving average MI. This dynamic model can be expressed through these two variables to describe a person’s health status at any moment of time.
The year 2017, from 1/1/2017 – 12/31/2017, Period A was the author’s “best performed” period, i.e. lowest numerical scores (means the highest performance) on his 4 input categories, 6 output categories, MI, and GHSU.
Period B, from 1/1/2018 through 6/30/2019, is the “not-so-perfect performed” period, i.e. higher numerical scores (means poorer performance) on all categories. During period B, the author has attended more than 35 medical conferences worldwide to present more than 70 medical papers. In addition, during this 18-month period, he wrote a total of 162 medical papers with 22 full-length articles published in various medical journals. In summary, during period B, he overworked himself at the cost of damaging his overall health conditions, possibly shortening his life expectancy to some degree.
Figures 1 and 2 illustrate the lifestyle and medical conditions performance score comparison between the two periods graphically. He focused on four subjects: MI, GHSU, stress level, and daily life routine regularity.
Figure 1: MI/GHSU and Stress/Daily routine of Period A (1/1/2017 - 12/31/2017)
Figure 2: MI/GHSU and Stress/Daily routine of Period B (1/1/2018 - 6/30/2019)
Figure 3 shows both the data table of numerical comparison and a bar chart of performance percentages against baseline conditions. Specifically, 73.5% is the baseline for both MI and GHSU, healthy if <73.5% and unhealthy if >73.5%. He uses 70% as the best possible condition for stress level and 50% as the best possible condition for daily life routines.
Figure 3: Comparison between Period A and Period B (MI, GHSU, Stress, and Daily routine)
Although his score of MI and GHSU has only increased (i.e. worsen) by 2% from Period A to Period B, most of his metabolism categories have worse performance scores in Period B.
Most medical research have shown that the majority of people, who lived long lives had a simple but routine lifestyle. Therefore, let us focus on the category of “life routine regularity”. His performance score for this category has increased (i.e. worsen) by 2%. More specifically, this increased numerical score (i.e. worsen performance) is the combined results from air-flights, hotel meals, disturbance of food, exercise routines, weather changes, living environment changes, jetlag, and sleep pattern disruption.
It is quite interesting to find out that his stress level has no significant change, the comparison factor between Period A and B is 100% (i.e. no change). This is probably due to the fact that medical research for him is his personal hobby unlike most working people, which is the ways and means to make a living with the purpose of gaining fame, power, or money. In addition, he has not suffered any stress from a “boss” and some “deadlines” from his research like other working people with normal jobs.
The list of daily life routine is shown in Figure 4 which has many items to factor in. Therefore, it is difficult to achieve a perfect score in this daily life routine category. His performance score in this category was 145% in Period A and 148% in Period B, which is an increase of 3%.
Figure 4: Daily life routine
This big data analytics is based on ~600,000 data over 2.5 years. His developed metabolism model has shed some light about the impact on his life longevity due to his overall metabolic changes, especially his stress level and life routine regularity. Based on the findings from this specific analysis, the author has decided to change his lifestyle and work on a different approach to deliver and distribute his medical research results which does not involve a heavy travel schedule.
His metabolism model is an effective tool to investigate the subject of geriatrics and longevity. Moving from the inner circle toward the outside rings, Figure 5 depicts that lifestyle management leading into a good metabolic state, and then converts into a strong immunity to fight against three major diseases categories, chronic diseases and complications (50% of death), cancers (29% of death), and infectious diseases (11% of death), with the remaining 10% of non-diseases related to death cases. This is a logical way to achieve longevity which is the core of geriatrics. References 1 through 4 provide more details regarding the author’s work in this research area.
Figure 5: From lifestyle through metabolism, immunity, diseases and then death
- Gerald C. Hsu, eclaireMD Foundation, USA. April 2020. No. 223: “Effective health age resulting from metabolic condition changes and lifestyle maintenance program”
- Gerald C. Hsu, eclaireMD Foundation, USA. April 2020. No.280: ”A geriatric study of self-recovering diabetes conditions (GH-Method: Math-physical medicine)
- Gerald C. Hsu, eclaireMD Foundation, USA. December 2019. No.235: ”Linkage among metabolism, immune system, and various diseases using GH-Method: math-physical medicine (MPM)
- Gerald C. Hsu, eclaireMD Foundation, USA. December 2019. No.263: ”Risk probability of having a metabolic disorder induced cancer (GH-Method: MPM)”