GH-METHODS

Math-Physical Medicine

NO. 324

A Neurocommunication Model Between the Brain and Liver Regarding Glucose Production and Secretion in Early Morning Using GH-Method: Math-Physical Medicine

Corresponding Author: Gerald C. Hsu, eclaireMD Foundation, USA.

Abstract
This article addresses the author’s hypothesis on the neurocommunication model existing between the brain and liver regarding production and glucose secretion in the early morning. This is based on the observation of the difference between glucose at wake-up moment in the
morning for the fasting plasma glucose (FPG), and glucose at the first bite of breakfast for the glucose at 0 min or “open glucose” of postprandial plasma glucose (PPG).

All the 8 identified glucose of breakfast PPG are higher than the 8 glucose at the time of wakeup by a difference of an average of 8 mg/dL. The value difference using method B of continuous glucose monitoring (CGM) sensor glucose during the COVID-19 period offers the most accurate picture and credible glucose difference of 8 mg/dL between his FPG at the wake-up moment and PPG at the first bite of breakfast.

The author believes that the brain senses when a person wakes up due to different kinds of stimuli from many sources, including the eye, environment, and even internal organs, which will alert the body to be in an active mode requiring energy through glucose. Even though the person has not eaten anything or is not actively moving, the brain issues a marching order to the liver to produce or release glucose for the body to use in the forthcoming day. This hypothesis can currently explain why his glucose of eating his breakfast is ~8 mg/dL higher than his FPG at wake-up.

Introduction
This article addresses the author’s hypothesis on the neurocommunication model existing between the brain and liver regarding production and glucose secretion in the early morning. This is based on the observation of the difference between glucose at wake-up moment in the morning for the fasting plasma glucose (FPG), and glucose at the first bite of breakfast for the glucose at 0 min or “open glucose” of postprandial plasma glucose (PPG).

Methods
1. Data collection
The author started measuring his glucose since 1/1/2012 using traditional finger-piercing and test-strip (finger glucose) 4 times each day, once in the early morning (FPG) when he just wakes up from his sleep, and 3 times at 2 h after each meal (PPG).

In addition, since 5/5/2018, he applied a continuous glucose monitoring (CGM) device on his upper arm and collected ~96 glucose each day at a time interval of 15 min. With this CGM-based sensor collected glucose (sensor glucose), he has defined his sensor FPG as the average glucose of 28 values between 00:00 am (midnight) and 07:00 am (around the time of the first bite of breakfast). In this particular analysis, he will not use the average FPG within 7 h of nocturnal sleep time. Also, he selected a 3 h (180 min) timespan after the first bite of the meal as his standard sensor PPG timeframe. As a result, he will only use his glucose at the first bite of breakfast, which is 0 min of his breakfast PPG
waveform, and disregard all of the other glucose data.

2. Background
To learn more about the GH-method: math-physical medicine (MPM) research methodology, readers can review his article, Biomedical research methodology based on GH-method: math-physical medicine, to understand his MPM analysis method [1].

For the past 12 months, he has researched and written approximately 10 medical papers, regarding the specific neurocommunication model existing between the brain and some internal organs, specifically the stomach, liver, and pancreas via observing and analyzing his glucose variances from his nearly 2 million collected data [2].

For the past ~8 months during the COVID-19 quarantined period (virus period), he has achieved better results on his glucose control and metabolism maintenance due to his non-traveling, peaceful, and routine lifestyle [3]. His average daily glucose was 115 mg/dL over a period of ~20 months, from 5/5/2018 through 1/18/2020 (pre-virus period), in comparison with an average daily glucose of 108 mg/dL for the recent ~8 months of virus period.

Recently, during the virus period, he noticed a specific phenomenon of glucose rapidly rising after his wake-up moment until the first bite of breakfast. Usually, he measures his FPG after he wakes up from his sleep, then measures his blood pressure and body weight to input these biomarker data into his app software. Finally, he prepares his simple breakfast, normally containing egg and coffee. During this entire time period, usually within 30–45 min, he does not eat anything else or has any physical activity (his total walking steps is around 100 steps on average). Surprisingly, he noticed that his fast-rising glucose makes his glucose at the moment from the first bite of his meal higher than the
glucose at his wake-up moment. The timespan between these two moments is within ~45 min without any external influences from diet and exercise; therefore, he wonders why this occurred and what is the difference in glucose over a longer period of time?

Results

  • First, he chose 3 different periods:
    • Virus period: (1/19/2020–9/6/2020)
    • Pre-virus period: (5/5/2018–1/18/2020)
    • Total period: (5/5/2018–9/6/2020)

Secondly, he chose 3 different analytical methods described below to calculate the glucose values he desired:

  • Method A: He uses time series analysis to calculate his average FPG value measured at wake-up moment. Please note that he used finger FPG for the pre-virus period and CGM sensor FPG at wake-up moment for virus period. Therefore, his glucose data comparison during pre-virus period has deteriorated on data accuracy due to data inconsistency between finger FPG and sensor PPG. In his previous research papers, he already identified his average sensor glucose as being higher than his average finger glucose. As a result, his glucose data comparison during the virus period has the highest degree of data accuracy due to data consistency between sensor FPG and sensor PPG.
  • Method B: He uses segmented pattern analysis to calculate and generate a “synthesized” PPG waveform of breakfast and then single out the breakfast PPG at 0 min. He also applies the “candlestick K-line” model [4] to double-check his breakfast PPG at 0 min (i.e., “open” glucose of breakfast candlestick) to make sure these two values are identical. Please note that this second step uses CGM data only since finger glucose contains one-point data which cannot represent a curve or waveform.
  • Method C: He uses synthesized all-day glucose waveform from 00:00 throughout 23:45 with a total of 96 glucose data-points for each day. He then summarized those 231 days’ data for the virus period, 620 days’ data for the pre-virus period, and 851 days’ data for the total period to generate a synthesized all-day glucose waveform. He chose two glucose values at 06:00 am as his “approximate” wake-up moment and 07:00 am as his “approximate” first bite moment of breakfast. Although he is a very disciplined person, he cannot wake-up every morning consistently at 06:15 and eats his breakfast at 07:00 every day. Therefore, the glucose data comparison using method C has the highest margin of error, i.e., lowest data accuracy.

The figures (Figure 1, 2 and 3) show the resulting diagrams of his measured FPG at wake-up moment, breakfast PPG waveform, breakfast PPG K-line, PPG at first bite of breakfast, and the glucose difference between these 2 different moments in the 3 respective periods using method A and method B.

Figure 1: Virus period (method A and method B)
Figure 2: Pre-virus period (method A and method B)
Figure 3: Total period (method A and method B)

The summarized glucose differences are listed below:

  • Virus: 8 mg/dL (most accurate)
  • Pre-virus: 10 mg/dL (less accurate)
  • Total: 9 mg/dL (hybrid in-between)
  • Average: 9 mg/dL

The figures (Figure 4, 5 and 6) show the diagram results of his synthesized daily glucose curve over 24 h with a data table containing his FPG at the wake-up moment and his PPG at the first bite of his breakfast, and the glucose difference between these 2 different moments in the 3 respective periods using method C. As mentioned above, this set of glucose comparison has the lowest data accuracy because his exact wake-up time is not consistently at 06:15 am (usually between 5:30 am and 7:30 am), and the time of the first bite of breakfast is not consistently at 07:00 am (about 80% at 7:00 am).

Figure 4: Virus period (method C)
Figure 5: Pre-virus period (method C)
Figure 6: Total period (method C)

The summarized glucose differences are listed below:

  • Virus: 10 mg/dL (higher than A and B)
  • Pre-virus: 4 mg/dL (longer period)
  • Total: 7 mg/dL (hybrid in-between)
  • Average: 7 mg/dL

By analyzing the above observations of 8 glucose difference values, except the 4 mg/dL glucose difference during the pre-virus period using method C (i.e., using a synthesized daily glucose curve and two fixed time instants), all of the other 7 glucose difference values are between 7 mg/dL–10 mg/dL. However, the result of 8 mg/dL glucose difference value using method B of CGM sensor glucose during the virus period offers the most accurate picture and reliable glucose difference of 8 mg/dL between his FPG at the wake-up moment and PPG at the first bite (i.e., 0 min) of his breakfast.

The figure (Figure 7) contains the most important and conclusive information for this article because it shows the background data table and its associated bar charts. It is obvious that all of the glucose of breakfast PPG at first bite are higher than those glucose at the wake-up moment, by a difference of an average amount of 8 mg/dL.

Figure 7: Data table and bar chart of three periods (~8 mg/dL of glucose difference in early morning)

Now the question is why this phenomenon occurred.

The author believes that the brain senses when a person wakes up due to different kinds of stimuli from many sources, including the eye, environment, and even internal organs, which will alert the body to be in an active mode requiring energy through glucose. Even though the person has not eaten anything or is not actively moving, the brain issues a marching order to the liver to produce or release glucose for the body to use in the forthcoming day. As a result, this currently explains why his glucose of eating his breakfast is higher than his FPG at the wake-up moment.

The author developed his hypothesis using a method he learned in business statistics, decision making through elimination. To explain his observed phenomenon of higher glucose, he collected 8 possible sources or inputs: A is diet, B is exercise, C is body weight, D is weather temperature, E is stress, F is an illness, G is sleep condition and His the unidentified source. For 2 glucose values occurring within ~45 min on the same day and in the same living environment, he could rule out possible inputs of C, D, E, F, and G. Besides, C for body weight and D for weather temperature are already identified as the 2 major influential factors in his predicted FPG. Also, he does not have any influences from A for diet and B for exercise before eating his breakfast. As a result, the remaining factor is H for the un-identified source or input factor. The unknown factor is the brain through the nervous system communicating with the internal organs. This is how the author established his hypothesis via the specific evidence of glucose difference value for the early morning.

Conclusion
This article is slightly different from the author’s earlier research work focusing on the same subject of neurocommunication models between the brain and organs, such as the stomach, liver, and pancreas. His previous papers were based on the observation of PPG differences using the same food material and different cooking methods, resulting with food in different physical states. This article has nothing to do with food but addresses the same neurological phenomenon through observation of his 2 glucose in the early morning.

As he conducts more research on neuroscience, the more fascinated he gets with this particular subject. In the body, all of the organs are interconnected with the brain via the nervous system and blood system. Lifestyle affects the entire body; therefore, lifestyle is linked to metabolism which further affects the immune system to defend the body from many diseases. As a result, we must manage our lifestyle extremely well to maintain good health.

References

  1. Hsu GC. Biomedical research methodology based on GH-method: math-physical medicine (No. 310). J App Mat Sci & Engg Res. 2020;4(3):116-24.
  2. Hsu GC. Self-recovery of pancreatic beta cell’s insulin secretion based on annualized fasting plasma glucose, baseline postprandial plasma glucose, and baseline daily glucose data using GH-method: math-physical medicine. eclaireMD Foundation. 2020:297.
  3. Hsu GC. Diabetes control and metabolism maintenance during COVID-19 period in comparison to three other periods using GH-method: math-physical medicine. J Edu Psyc Res. 2020;2(3):153-57.
  4. Hsu GC. Comparison study of PPG characteristics from candlestick model using GH-method: math-physical medicine. J Nutr Diet Pract. 2020;4(3):1-6.

Copyright © 2020 Hsu GC. This is an open access article and is distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.